The first in the world – KKU’s Kapillariasis Test Kit that shows result in 15 minutes

Khon Kaen University and Thailand Research Funds held a conference and press release on “Kapillariasis ICT Kit-showing results within 15 minutes to naked eyes”
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10 ม.ค. 2561    Raviporn Saisaenthong

          On January 5, 2017, Assoc. Prof. Dr. Kittichai Triratanasirichai, Khon Kaen University President, Assoc. Prof. Dr. Chanchai Panthongwiriyakul (MD), Dean of Faculty of Medicine, Professor Sutthipan Jitpimonmas (MD), Director of Office of Thailand Research Fund, Professor Wanchai Maleewong (MD), a senior research scholar, Professor Phewpan Maleewong (MD), Head of the Research Team gave a press conference to 70 representatives from hospitals in the Northeast at Sarasin Room, Sirikunakorn Building, 2nd Floor, Office of the President, Khon Kaen University.

          The conference and press conference was aimed to transfer the research work on Kapillariasis ICT Kit (Fast) for diagnosis Kapillariasis in patients by Professor Wanchai Maleewong (MD), who was supported by Thailand Research Funds and Faculty of Medicine of Khon Kaen University.

          Assoc. Prof. Dr. Kittichai Triratanasirichai, Khon Kaen University President said that Thailand is expediting the policy of “New Engines of Growth”, which emphasizes research and creativity, innovations, and science towards the target of Thailand 4.0. Khon Kaen University as the center of knowledge of the region is responding to the policy by the research work on Kapillariasis ICT Kit (Fast), a very modernized kit that is not expensive and can be operated without any expert.

          “Thanks the research team for sacrificing your time to create the world innovation. This kit is the first of its kind in Thailand, which is also easy and quick to use. The work is a pride of our university and demonstrates that we are stepping forward according to our vision towards a world-class research university. The kit will be useful in the field of parasitology and the patients having chronic diarrhea from worms, who will now be able to survice and recover from the disease. Social losses will also be reduced,” Assoc. Prof. Dr. Kittichai Triratanasirichai said.

           Professor Sutthipan Jitpimonmas (MD), Director of Office of Thailand Research Fund said, “Thailand Research Funds has a vision to be an organization with excellence and a leader in administration and management of research in Asia and to support utilization of research outcomes. Kapillariasis ICT Kit (Fast) is the work under to collaboration between Thailand Research Fund and Faclty of Medicine of Khon Kaen University. Professor Phewpan Maleewong (MD) is the Head of the research team. The kit has been submitted for patent rights and Thailand’s invention.

           Professor Phewpan Maleewong (MD) from Department of Parasitology of faculty of Medicine, Khon Kaen University, head of the research team said that the research work has been published in an international periodical. Kapillariasis ICT Kit (Fast) is the first of its kind in the world under the category of fast test kit to diagnose Kapillariasis in people using the Lateral Flow Immunoassay technique. There is an antigen on the kit, which is extracted from Trichinella spiralis made to specifically react with serum or lymph of a patient infected with Kapillaria. When dilute lymph is dropped with a solution into the kit’s hole, the result can be shown within 15 minutes to naked eyes. Kapillaria infection will show a positive result with two pink stripes shown, whereas for the negative result only one pink stripe is shown. The sensibility value is 100% and the specificity is 96.6%.

         “Kapillariasis occurs from a small round worm in people’s intestine. It is widespread in Isan; with the incidence of chronic Kapillariasis close to Cholangiocarcinoma patients, i.e. 12 – 33 cases per 10,000 people. The cause is from fresh water scale fish. If compared to the rate of live fluke disease, it can be anticipated that over 13 million Thai people and over 2 million Laos eat raw scale fish and all are subject to Kapillariasis. Formerly, the researchers produced Immunoblot kit and ELISA technique to diagnose Kapillariasis. Even though the accuracy is 100%, but both methods required 6 and 2-3 hours, respectively, resulting in tardiness of diagnosis. Kapillariasis ICT Kit (Fast), on the contrary, requires only 15 minutes to show the result. It can diagnose the first stage of infection and can diagnose chronic diarrhea from other causes such as colon cancer, AIDs, thyroid toxicity; and hence the rate of bed occupation and costs from examination are reduced. The patients have more chances to survive with the use of cheap equipment that cost only a hundred or so,” Professor Phewpan Maleewong said.  

            Kapillariasis is caused by eating uncooked food or fresh water fish with scales such as pla sew, pla khaw, the same types of fish that cause liver fluke disease and cholangiocarcinoma. Kapillariasis is a small round worm that hides itself in the tissue of the intestine. It measures 2-5mm long and is viviparous. This means over ten thousands of them in the intestine. The patient then suffers chronic diarrhea, weight reduction, inflammation, and malnutrition. If the worms are not killed under treatment, all patients will die.

After the press conference, Khon Kaen University gave out Kapillariasis ICT Kit (Fast) to representatives from hospitals in the Northeast for diagnosing their patients. If interested please contact Professor Phewpan Maleewong (MD) Professor Phewpan Maleewong (MD): 097-3062345 Email: pewpan@kku.ac.th

 

 


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